(2016) Effects of berberine on acquisition and reinstatement of morphine-induced conditioned place preference in mice. Avicenna Journal of Phytomedicine. pp. 198-204. ISSN 2228-7930 (Print) 2228-7930 (Linking)
Full text not available from this repository.
Abstract
OBJECTIVE: It has been shown that berberine, a major component of Berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (Da) and N-methyl-D-aspartate (NMDA) contributing to rewarding and reinforcing effects of morphine. Drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. In the present study, we investigated the alleviating effects of berberine on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice. MATERIALS AND METHODS: In male NMRI mice, the acquisition of CPP was established by 40 mg/kg of morphine sulphate injection and extinguished after the extinction training and reinstated by a 10 mg/kg injection of morphine. The effects of different doses of berberine (5, 10, and 20 mg/kg) on the acquisition and reinstatement induced by morphine were evaluated in a conditioned place preference test. RESULTS: The results showed that intraperitoneal administration of berberine (5, 10, and 20 mg/kg) did not induce conditioned appetitive or aversive effects. Injection of berberine (10 and 20 mg/kg) 2 h before the morphine administration reduced acquisition of morphine-induced CPP. In addition, same doses of berberine significantly prevented the reinstatement of morphine-induced CPP. CONCLUSION: These results suggest that berberine can reduce the acquisition and reinstatement of morphine-induced conditioned place preference and may be useful in treatment of morphine addiction.
Item Type: | Article |
---|---|
Keywords: | Berberine Berberis vulgaris Conditioned Place Preference Morphine Mouse |
Divisions: | |
Page Range: | pp. 198-204 |
Journal or Publication Title: | Avicenna Journal of Phytomedicine |
Volume: | 6 |
Number: | 2 |
ISSN: | 2228-7930 (Print) 2228-7930 (Linking) |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2892 |
Actions (login required)
View Item |