(2016) Investigating the Apoptosis Ability of Ethylenediamine 8-Hydroxyquinolinato Palladium (II) Complex. Advanced Pharmaceutical Bulletin. pp. 449-453. ISSN 2228-5881 (Print) 2228-5881 (Linking)
Full text not available from this repository.
Abstract
Purpose: High solubility, low renal toxicity and apoptosis-inducing ability of palladium complexes are the reasons for their synthesis. Methods: In vitro cytotoxic study of previously synthesized Pd(en)(8HQ)NO3 , was carried out on breast cancer MCF-7 cell lines and prostate cancer DU145 cell lines. DNA fragmentation indicative of apoptotic was also evaluated by TUNEL assay on DU145 cell line. Results: FT-IR spectra of final complex confirmed the existence of chelating ligands. The DU145 cells unlike the MCF-7 cells, demonstrated the significant influence of the Pd (II) complex. The IC50 values of Pd(en)(8HQ)NO3 and cisplatin on DU145 cells were 27 and 8.3 muM, respectively. Moreover, nearly 38% apoptosis was evident in DU145 cells after treatment with Pd(en)(8HQ)NO3. Conclusion: Pd(en)(8HQ)NO3 has great potential in DNA binding and induction of apoptosis; thus it can be used in the future against prostate cancer.
Item Type: | Article |
---|---|
Keywords: | 8-hydroxyquinoline Du145 Fluorescent microscope Mcf-7 Palladium complex TUNEL assay |
Divisions: | |
Page Range: | pp. 449-453 |
Journal or Publication Title: | Advanced Pharmaceutical Bulletin |
Volume: | 6 |
Number: | 3 |
Identification Number: | 10.15171/apb.2016.058 |
ISSN: | 2228-5881 (Print) 2228-5881 (Linking) |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2876 |
Actions (login required)
View Item |