(2016) Effects of Luteolin on Intra Peritoneal Adhesion Bands in Rat. Journal of Fundamental and Applied Sciences. pp. 1-11. ISSN 1112-9867
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Abstract
Intraperitoneal adhesion is consequences of surgery in the abdomen and result in infertility, intestinal obstruction and pelvic pain. Luteolin (LUT) is a natural product that has anti-inflammatory, anti-oxidant, anti-angiogenic effects and its effects were evaluated as anti-adhesive in animal model. 30 male rats assigned in to 5 groups (6 animals in each group) of LUT 10, 25 and 50 mg/kg and normal saline as a control group and intact animals. Animal anesthetized and peritoneal injury was conducted and seven days following to surgery, they scarified. Microscopic, macroscopic, lipid peroxidation changes and TNF-alpha plasma concentration were evaluated. LUT reduced microscopic and macroscopic injury and lipid peroxidation significantly. Plasma concentrations of TNF-alpha didn't show any changes. LUT reduces lipid peroxidation, adhesion band formation in microscopic and macroscopic scale but no change in the serum levels of TNF-alpha.
Item Type: | Article |
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Keywords: | luteolin adhesion bands tnf-alpha lipid peroxidation intraabdominal adhesions prevention cox-2 cells |
Divisions: | |
Page Range: | pp. 1-11 |
Journal or Publication Title: | Journal of Fundamental and Applied Sciences |
Volume: | 8 |
Identification Number: | 10.4314/jfas.8vi2s.1 |
ISSN: | 1112-9867 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2646 |
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