Abstract

Purpose: High solubility, low renal toxicity and apoptosis-inducing ability of palladium complexes are the reasons for their synthesis. Methods: In vitro cytotoxic study of previously synthesized Pd(en)(8HQ)NO3 , was carried out on breast cancer MCF-7 cell lines and prostate cancer DU145 cell lines. DNA fragmentation indicative of apoptotic was also evaluated by TUNEL assay on DU145 cell line. Results: FT-IR spectra of final complex confirmed the existence of chelating ligands. The DU145 cells unlike the MCF-7 cells, demonstrated the significant influence of the Pd (II) complex. The IC50 values of Pd(en)(8HQ)NO3 and cisplatin on DU145 cells were 27 and 8.3 muM, respectively. Moreover, nearly 38% apoptosis was evident in DU145 cells after treatment with Pd(en)(8HQ)NO3. Conclusion: Pd(en)(8HQ)NO3 has great potential in DNA binding and induction of apoptosis; thus it can be used in the future against prostate cancer.