Abstract

Intraperitoneal adhesion is consequences of surgery in the abdomen and result in infertility, intestinal obstruction and pelvic pain. Luteolin (LUT) is a natural product that has anti-inflammatory, anti-oxidant, anti-angiogenic effects and its effects were evaluated as anti-adhesive in animal model. 30 male rats assigned in to 5 groups (6 animals in each group) of LUT 10, 25 and 50 mg/kg and normal saline as a control group and intact animals. Animal anesthetized and peritoneal injury was conducted and seven days following to surgery, they scarified. Microscopic, macroscopic, lipid peroxidation changes and TNF-alpha plasma concentration were evaluated. LUT reduced microscopic and macroscopic injury and lipid peroxidation significantly. Plasma concentrations of TNF-alpha didn't show any changes. LUT reduces lipid peroxidation, adhesion band formation in microscopic and macroscopic scale but no change in the serum levels of TNF-alpha.