(2021) Green synthesis of bimetallic ZnO–CuO nanoparticles and their cytotoxicity properties. Scientific Reports. ISSN 20452322 (ISSN)
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Abstract
In this study, a simple and green strategy was reported to prepare bimetallic nanoparticles (NPs) by the combination of zinc oxide (ZnO) and copper oxide (CuO) using Sambucus nigra L. extract. The physicochemical properties of these NPs such as crystal structure, size, and morphology were studied by X-ray diffraction (XRD), field emission gun scanning electron microscopy (FEG-SEM), and transmission electron microscopy (TEM). The results suggested that these NPs contained polygonal ZnO NPs with hexagonal phase and spherical CuO NPs with monoclinic phase. The anticancer activity of the prepared bimetallic NPs was evaluated against lung and human melanoma cell lines based on MTT assay. As a result, the bimetallic ZnO/CuO NPs exhibited high toxicity on melanoma cancer cells while their toxicity on lung cancer cells was low. © 2021, The Author(s).
| Item Type: | Article |
|---|---|
| Keywords: | antiinfective agent copper cuprous oxide cytotoxin metal nanoparticle plant extract zinc oxide A-549 cell line chemistry green chemistry human infrared spectroscopy microbial sensitivity test plant leaf procedures Sambucus nigra transmission electron microscopy tumor cell line X ray diffraction A549 Cells Anti-Bacterial Agents Cell Line, Tumor Cytotoxins Green Chemistry Technology Humans Metal Nanoparticles Microbial Sensitivity Tests Microscopy, Electron, Transmission Plant Extracts Plant Leaves Spectroscopy, Fourier Transform Infrared X-Ray Diffraction |
| Divisions: | |
| Journal or Publication Title: | Scientific Reports |
| Volume: | 11 |
| Number: | 1 |
| Identification Number: | 10.1038/s41598-021-02937-1 |
| ISSN: | 20452322 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/4330 |
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