(2022) Evaluation of the anti-melanogenic activity of nanostructured lipid carriers containing auraptene: A natural anti-oxidant agent. Nanomedicine Journal. pp. 57-66. ISSN 2322-3049
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Abstract
Objective(s): In this work, we loaded Auraptene (AUR) into nanostructured lipid carriers (NLCs) and performed an assessment on inhibitory activities of the obtained AUR-NLCs on melanogenesis. Materials and Methods: AUR-NLCs were prepared through a high shear homogenization and ultrasound method. Results: Entrapment efficiency and Particle size of the optimized formulation were 103.1 +/- 4.9 nm and 89.56 +/- 3.75. The TEM outcomes exhibited the spherical shape of our nanoparticles, while the DSC analysis revealed the lack of any drug-lipid incompatibility throughout the formulations. A prolonged drug-release was observed from AUR-NLCs when compared to the AUR-solution. According to results, this product can significantly attenuated the activity of cellular tyrosinase and ROS content with minimal cytotoxic effects in B16F10 cell line, which in contrast to AUR-solution. Moreover, the western blotting analysis was indicative of AUR-NLCs ability to inhibit melanogenesis through the suppression of MITF and act much more efficiently than AUR-solution. Conclusion: AUR-NLCs can offer merits as a natural anti-tyrosinase agent for the treatment of hyperpigmentory disorders.
Item Type: | Article |
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Keywords: | Anti-tyrosinase Auraptene Melanin Melanogenesis NLC in-vitro skin permeation loaded nlc nanoparticles optimization Science & Technology - Other Topics |
Divisions: | |
Page Range: | pp. 57-66 |
Journal or Publication Title: | Nanomedicine Journal |
Volume: | 9 |
Number: | 1 |
Identification Number: | 10.22038/nmj.2021.62354.1645 |
ISSN: | 2322-3049 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/4264 |
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