(2022) A Cohort Study on the Immunogenicity and Safety of the Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV) in Patients With Breast Cancer; Does Trastuzumab Interfere With the Outcome? Frontiers in Endocrinology. p. 7. ISSN 1664-2392
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Abstract
AimTo determine the efficacy and safety of inactivated SARS-CoV-2 vaccine (BBIBP-CorV) in patients with breast cancer. MethodsIn this multi- institutional cohort study, a total of 160 breast cancer patients (mean age of 50.01 +/- 11.5 years old) were assessed for the SARS-CoV-2 Anti-Spike IgG and SARS-CoV2 Anti RBD IgG by ELISA after two doses of 0.5 mL inactivated, COVID-19 vaccine (BBIBP-CorV). All patients were followed up for three months for clinical COVID-19 infection based on either PCR results or imaging findings. Common Terminology Criteria for Adverse Events were used to assess the side effects. ResultsThe presence of SARS-CoV-2 anti-spike IgG, SARS-CoV2 anti-RBD IgG, or either of these antibodies was 85.7, 87.4, and 93.3. The prevalence of COVID-19 infection after vaccination was 0.7, 0 and 0 for the first, second and third months of the follow-up period. The most common local and systemic side-effects were injection site pain and fever which were presented in 22.3 and 24.3 of patients, respectively. DiscussionThe inactivated SARS-CoV-2 vaccine (BBIBP-CorV) is a tolerable and effective method to prevent COVID-19.
Item Type: | Article |
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Keywords: | breast cancer inactivated SARS-CoV-2 vaccine seroconversion SARS-CoV2 COVID-19 vaccine cancer malignancy Iran immune-system chemotherapy statistics mortality Endocrinology & Metabolism |
Divisions: | |
Page Range: | p. 7 |
Journal or Publication Title: | Frontiers in Endocrinology |
Volume: | 13 |
Identification Number: | 10.3389/fendo.2022.798975 |
ISSN: | 1664-2392 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/4262 |
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