(2022) Study of in vitro cytotoxic performance of biosynthesized a-Bi2O3 NPs, Mn-doped and Zn-doped Bi2O3 NPs against MCF-7 and HUVEC cell lines. Journal of Materials Research and Technology-Jmr&T. pp. 140-150. ISSN 2238-7854
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Abstract
Green-synthesized nanoparticles can be applicable in designing an effective, efficient, and low-risk treatment for cancer. In this regard, we introduced a novel and eco-friendly method for preparing pure alpha-Bi2O3, Mn-doped Bi2O3, and Zn-doped Bi2O3 nanoparticles with potent cytotoxic activity through the application of Salvadora persica extract as the green reactive, reducing, and capping agent. The biosynthesis and characterization of our product was supported by the results of powder X-ray Powder Diffraction (PXRD), Energy Dispersive X-Ray (EDAX), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), Fourier-Transform Infrared (FT-IR), and Raman analysis. The outcomes of SEM analysis displayed the porous morphology of pure alpha-Bi2O3 nanoparticles, whereas the doping of Zn and Mn turned their structure into a conical shape. The TEM results presented the hexagonal shape of pure alpha-Bi2O3 NPs with a particle size mean of 46 nm. Additionally, the Zn-doped Bi2O3 nanoparticles consisted spherical particles with 32 nm of size mean, while the Mn-doped Bi2O3 NPs were approximately hexagonal with a particle size mean of 41 nm. The success of doping process was proven by the EDX analysis. Next to their high potential in cytotoxic performance against cancer cell line, the results of MTT assay confirmed the potent cytotoxic activity of synthesized nanoparticles against breast cancer (MCF-7) and human umbilical vein endothelial (HUVEC) cells as well. Considering these observations, these products can be suggested as a proper candidate for biological and medical applications. (C) 2022 The Author(s). Published by Elsevier B.V.
Item Type: | Article |
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Keywords: | Doped Bi2O3 NPs Umbilical vein endothelial MCF-7 a-Bi(2)O(3)NPs Green synthesis green synthesis nanoparticles cancer Materials Science Metallurgy & Metallurgical Engineering |
Divisions: | |
Page Range: | pp. 140-150 |
Journal or Publication Title: | Journal of Materials Research and Technology-Jmr&T |
Volume: | 19 |
Identification Number: | 10.1016/j.jmrt.2022.05.002 |
ISSN: | 2238-7854 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/4237 |
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