(2018) Anticancer activity evaluation of green synthesised gold–silver alloy nanoparticles on colourectal HT-29 and prostate DU-145 carcinoma cell lines. Micro and Nano Letters. pp. 1475-1479. ISSN 17500443 (ISSN)
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Abstract
Nanotechnology is an interesting way to produce and deal with fascinating features of materials. Metal nanoparticles offer a vast spectrum of potential applications in medicine and pharmaceutical sciences due to advances in nanotechnology research. This study was aimed to evaluate the anticancer properties of gold–silver (Au–Ag) alloy nanoparticles, which were synthesised using a green method by Galega officinalis ethanolic extract. The antitumour activity of biosynthesised nanoparticles has been assessed in vitro using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay on DU-145 and HT-29, prostate and colon cell lines, respectively. The Au–Ag alloy nanoparticles activity to inhibit the growth of cancer cell lines was recorded in terms of decrease in viable cell count in comparison with the control value. The spherical Au–Ag alloy nanoparticles with average size of 100 nm diameter were synthesised. The growth inhibition of the human prostate (DU-145) and colon carcinoma cell line (HT-29) has been found to be dose dependent. The calculated IC50 for the DU-145 cell line was 95.78 μg/ml after 24 h and for the HT-29 cell line was 70.66 µg/ml after 48 h. The results of this study suggest that Au–Ag alloy nanoparticles could be as an active substance against tumour cell lines and May be a beneficial treatment for cancer. © The Institution of Engineering and Technology 2018.
| Item Type: | Article |
|---|---|
| Keywords: | Cell culture Cells Diseases Metal nanoparticles Silver nanoparticles Urology 3-(4 ,5-Dimethylthiazol-2-yl)-2 ,5-diphenyl tetrazolium bromide Anticancer activities Anticancer properties Antitumour activity Carcinoma cell lines Colon carcinoma cells Nanotechnology research Pharmaceutical science Silver alloys alcohol Galega officinalis extract gold nanoparticle plant extract silver nanoparticle unclassified drug antineoplastic activity Article cancer inhibition cell viability clinical evaluation comparative study concentration response controlled study drug cytotoxicity drug efficacy drug mechanism DU145 cell line Galega Galega officinalis green chemistry HT-29 cell line human human cell IC50 in vitro study male MTT assay nanochemistry nanomedicine particle size viable cell count |
| Divisions: | |
| Page Range: | pp. 1475-1479 |
| Journal or Publication Title: | Micro and Nano Letters |
| Volume: | 13 |
| Number: | 10 |
| Identification Number: | 10.1049/mnl.2018.0235 |
| ISSN: | 17500443 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/4142 |
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