(2018) Assessment of expression of interferon γ (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer. World Journal of Surgical Oncology. ISSN 14777819 (ISSN)
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Abstract
Background: The role of long non-coding RNAs has been extensively appreciated in the contexts of cancer. Interferon γ-antisense RNA1 (IFNG-AS1) is an lncRNA located near to IFN-γ-encoding (IFNG) gene and regulates expression of IFNG in Th1 cells. Methods: In the present study, we evaluated expression of IFNG and IFNG-AS1 in 108 breast samples including tumoral tissues and their adjacent non-cancerous tissues (ANCTs) using real-time PCR. IFNG-AS1 was significantly upregulated in tumoral tissues compared with ANCTs (expression ratio = 2.23, P = 0.03). Results: Although the expression of IFNG was higher in tumoral tissues compared with ANCTs (relative expression = 1.89), it did not reach the level of significance (P = 0.07). IFNG expression was significantly higher in HER2-negative tumoral tissues compared with HER2-positive ones (P = 0.01) and in grade 1 samples compared with grade 2 ones (P = 0.03). No other significant difference was found in expressions of genes between other groups. Conclusion: Significant strong correlations were detected between expression of IFNG and IFNG-AS1 in both tumoral tissues and ANCTs. The present study provides evidences for participation of IFNG and IFNG-AS1 in the pathogenesis of breast cancer and warrants future studies to elaborate the underlying mechanism. © 2018 The Author(s).
| Item Type: | Article |
|---|---|
| Keywords: | Breast cancer IFNG IFNG-AS1 complementary RNA gamma interferon IFNG protein, human long untranslated RNA tumor marker adult aged Article breast carcinogenesis breast tissue cancer grading cancer tissue controlled study correlation analysis diagnostic test accuracy study diagnostic value female gene expression gene expression regulation gene function genetic identification human human tissue IFN G gene IFNG AS1 gene major clinical study real time polymerase chain reaction receiver operating characteristic sensitivity and specificity upregulation very elderly breast tumor case control study follow up genetics metabolism middle aged Paget nipple disease pathology prognosis Aged, 80 and over Biomarkers, Tumor Breast Neoplasms Carcinoma, Ductal, Breast Case-Control Studies Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Interferon-gamma RNA, Antisense RNA, Long Noncoding |
| Divisions: | |
| Journal or Publication Title: | World Journal of Surgical Oncology |
| Volume: | 16 |
| Number: | 1 |
| Identification Number: | 10.1186/s12957-018-1508-1 |
| ISSN: | 14777819 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/4109 |
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