(2018) Determination of carbamazepine in urine and water samples using amino-functionalized metal–organic framework as sorbent. Chemistry Central Journal. ISSN 1752153X (ISSN)
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Abstract
A stable and porous amino-functionalized zirconium-based metal organic framework (Zr-MOF-NH2) containing missing linker defects was prepared and fully characterized by FTIR, scanning electron microscopy, powder X-ray diffraction, and BET surface area measurement. The Zr-MOF-NH2 was then applied as an adsorbent in pipette-tip solid phase extraction (PT-SPE) of carbamazepine. Important parameters affecting extraction efficiency such as pH, sample volume, type and volume of eluent, amount of adsorbent, and number of aspirating/dispensing cycles for sample solution and eluent solvent were investigated and optimized. The best extraction efficiency was obtained when pH of 100 µL of sample solution was adjusted to 7.5 and 5 mg of the sorbent was used. Eluent solvent was 10 µL methanol. Linear dynamic range was found to be between 0.1 and 50 µg L−1 and limit of detection for 10 measurement of blank solution was 0.05 µg L−1. This extraction method was coupled to HPLC and was successfully employed for the determination of carbamazepine in urine and water samples. The strategy combined the advantages of fast and easy operation of PT-SPE with robustness and large adsorption capacity of Zr-MOF-NH2. © 2018, The Author(s).
Item Type: | Article |
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Keywords: | Carbamazepine Pipette-tip solid phase extraction Urine analysis Zirconium-based metal–organic framework |
Divisions: | |
Journal or Publication Title: | Chemistry Central Journal |
Volume: | 12 |
Number: | 1 |
Identification Number: | 10.1186/s13065-018-0446-x |
ISSN: | 1752153X (ISSN) |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/4106 |
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