(2020) Comparison of DNA and mRNA vaccines against cancer. Drug Discovery Today. pp. 552-560. ISSN 1878-5832 (Electronic) 1359-6446 (Linking)
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Abstract
Nucleic acid vaccines (NAVs) have recently been tested as a cancer therapy. DNA and mRNA vaccines deliver genetic information encoding tumor antigens (TAs) to the host, which then produces immune responses against cancer cells that express the TAs. Although NAVs are easy, safe, and simple to manufacture, they have not so far been considered viable alternatives to peptide vaccines. Choosing the right TAs, insufficient immunogenicity, and the immunosuppressive nature of cancer are some challenges to this approach. In this review, we discuss approaches that been used to improve the efficiency of anticancer NAVs.
Item Type: | Article |
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Keywords: | Animals Antigens, Neoplasm/*immunology Cancer Vaccines/*administration & dosage/immunology Humans Immunogenicity, Vaccine Neoplasms/immunology/*therapy Vaccines, DNA/administration & dosage/immunology Vaccines, Synthetic/administration & dosage/immunology |
Divisions: | |
Page Range: | pp. 552-560 |
Journal or Publication Title: | Drug Discovery Today |
Volume: | 25 |
Number: | 3 |
Identification Number: | 10.1016/j.drudis.2019.12.003 |
ISSN: | 1878-5832 (Electronic) 1359-6446 (Linking) |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3982 |
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