(2021) The effect of T helper (Th)/T cytotoxic (Tc) ratio on disease severity in type A hemophilia patients. Human antibodies. pp. 95-99. ISSN 1875-869X (Electronic) 1093-2607 (Linking)
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Abstract
BACKGROUND AND OBJECTIVES: The aim of this study was to investigate the T helper (Th) to T cytotoxic (Tc) ratio in children suffering from type A hemophilia disease and to evaluate the correlation of this ratio with disease severity. MATERIAL AND METHOD: Two mls of EDTA anti coagulated whole blood was collected. Immunophenotyping of lymphocytes count was carried out by FACS analysis using a double CD4 and CD8 kit. The mean +/- SD of absolute numbers of CD4 and CD8 lymphocytes/ml was calculated and the ratio of CD4/CD8 was evaluated by statistical method. RESULTS: Among 80 type A hemophilia patients, 66 (82.5) were male. The mean age was 15 +/- 3.51 years. 12 (15) of them were suffering from mild disease and 68 (85) had sever disease. The CD4 /CD8 ratio was obtained between 0.45 and 1.44 with mean1.79 +/- 0.78. The correlation between this ration and disease severity was 0.019. CONCLUSION: The results showed that CD4/CD8 ratio has correlation with disease severity in type A hemophilia patients, however there was no association between this ratio and gender.
Item Type: | Article |
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Keywords: | Adolescent CD8-Positive T-Lymphocytes Child *Hemophilia A Humans Male Severity of Illness Index T-Lymphocytes, Helper-Inducer CD4/CD8 ratio hemophilia disease |
Divisions: | |
Page Range: | pp. 95-99 |
Journal or Publication Title: | Human antibodies |
Volume: | 29 |
Number: | 1 |
Identification Number: | 10.3233/HAB-200434 |
ISSN: | 1875-869X (Electronic) 1093-2607 (Linking) |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3971 |
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