(2018) Clinical Relevance of Faecal Calprotectin Level in Infantile Colic: A Cross-sectional Survey. Iranian Journal of Neonatology. pp. 66-71. ISSN 2251-7510
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Abstract
Background: There is limited knowledge on the potential applicability of fecal calprotectin (f-CP) as an inflammatory screening parameter in infantile colic (IC). This study aimed to evaluate f-CP in neonates with IC as a useful diagnostic indicator regarding this condition. Methods: The present study was conducted on 100 cases, including 50 newborns with IC and 50 non-colicky neonates. The diagnosis of IC was fulfilled by the Wessel Criteria. The level of f-CP was determined by a specific enzyme-linked immunosorbent assay kit (Calprotectin ELISA, Eurolmmun, Germany). The statistical analysis was performed in SPSS software (version 19). Results: Out of 100 neonates, 57 cases were male and 43 subjects were female. The age spectrum ranged from 19-90 days (40.4 +/- 15.9). Colicky newborns were slightly younger (P=0.06) with higher birth weight compared to the infants without colic (P<0.0001). The level of f-CP was significantly higher in colicky neonates (113.7 +/- 98.2 mu g/g) than non-colicky cases (71.4 +/- 45.5 mu g/g) (P=0.007). Overall, 37, 30, 26, and 7 of the newborns showed f-CP levels<50, 50-100, 100-200, and >200 mu g/g, respectively. There was a significant difference regarding the distribution of these f-CP categories between neonates with IC and the cases without IC (P=0.02). There were no significant correlations between the f-CP and newborn age, pregnancy age, present or birth weights, and number of pregnancies. Receiver operating characteristic analysis rendered an area under the curve of 0.642 (95 CI: 0.534-0.748) (P=0.01). At the cut-off value of 74 mu g/g, f-CP showed sensitivity of 60 and specificity of 59 for the detection of IC. Conclusion: The results of this study revealed that the f-CP might be useful in the diagnosis of the IC.
Item Type: | Article |
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Keywords: | Calprotectin Infantile colic Intestinal inflammation Leukocyte L1 antigen complex children disease inflammation Pediatrics |
Divisions: | |
Page Range: | pp. 66-71 |
Journal or Publication Title: | Iranian Journal of Neonatology |
Volume: | 9 |
Number: | 4 |
Identification Number: | 10.22038/ijn.2018.29511.1399 |
ISSN: | 2251-7510 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3819 |
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