(2018) Anticancer activity evaluation of green synthesised gold-silver alloy nanoparticles on colourectal HT-29 and prostate DU-145 carcinoma cell lines. Micro & Nano Letters. pp. 1475-1479. ISSN 1750-0443
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Abstract
Nanotechnology is an interesting way to produce and deal with fascinating features of materials. Metal nanoparticles offer a vast spectrum of potential applications in medicine and pharmaceutical sciences due to advances in nanotechnology research. This study was aimed to evaluate the anticancer properties of gold-silver (Au-Ag) alloy nanoparticles, which were synthesised using a green method by Galega officinalis ethanolic extract. The antitumour activity of biosynthesised nanoparticles has been assessed in vitro using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay on DU-145 and HT-29, prostate and colon cell lines, respectively. The Au-Ag alloy nanoparticles activity to inhibit the growth of cancer cell lines was recorded in terms of decrease in viable cell count in comparison with the control value. The spherical Au-Ag alloy nanoparticles with average size of 100 nm diameter were synthesised. The growth inhibition of the human prostate (DU-145) and colon carcinoma cell line (HT-29) has been found to be dose dependent. The calculated IC50 for the DU-145 cell line was 95.78 g/ml after 24 h and for the HT-29 cell line was 70.66 mu g/ml after 48 h. The results of this study suggest that Au-Ag alloy nanoparticles could be as an active substance against tumour cell lines and may be a beneficial treatment for cancer.
Item Type: | Article |
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Keywords: | patient treatment nanomedicine biomedical materials cancer drug delivery systems nanobiotechnology tumours nanoparticles toxicology drugs anticancer activity evaluation green synthesised gold-silver alloy nanoparticles colorectal HT-29 DU-145 carcinoma cell lines metal nanoparticles anticancer properties green method antitumour activity biosynthesised nanoparticles colon cell lines cancer cell lines viable cell count spherical Au-Ag alloy nanoparticles growth inhibition human prostate DU-145 cell line HT-29 cell line active substance tumour cell lines Au-Ag alloy nanoparticle activity in-vitro cytotoxicity genotoxicity metformin toxicity growth assay Science & Technology - Other Topics Materials Science |
Divisions: | |
Page Range: | pp. 1475-1479 |
Journal or Publication Title: | Micro & Nano Letters |
Volume: | 13 |
Number: | 10 |
Identification Number: | 10.1049/mnl.2018.0235 |
ISSN: | 1750-0443 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3809 |
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