(2018) Assessment of expression of interferon gamma (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer. World Journal of Surgical Oncology. p. 7. ISSN 1477-7819
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Abstract
Background: The role of long non-coding RNAs has been extensively appreciated in the contexts of cancer. Interferon gamma-antisense RNA1 (IFNG-AS1) is an lncRNA located near to IFN-gamma-encoding (IFNG) gene and regulates expression of IFNG in Th1 cells. Methods: In the present study, we evaluated expression of IFNG and IFNG-AS1 in 108 breast samples including tumoral tissues and their adjacent non-cancerous tissues (ANCTs) using real-time PCR. IFNG-AS1 was significantly upregulated in tumoral tissues compared with ANCTs (expression ratio = 223, P= 0.03). Results: Although the expression of IFNG was higher in tumoral tissues compared with ANCTs (relative expression = 1.89), it did not reach the level of significance (P= 0.07). IFNG expression was significantly higher in HER2-negative tumoral tissues compared with HER2-positive ones (P = 0.01) and in grade 1 samples compared with grade 2 ones (P= 0.03). No other significant difference was found in expressions of genes between other groups. Conclusion: Significant strong correlations were detected between expression of IFNG and IFNG-AS1 in both tumoral tissues and ANCTs. The present study provides evidences for participation of IFNG and IFNG-AS1 in the pathogenesis of breast cancer and warrants future studies to elaborate the underlying mechanism.
Item Type: | Article |
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Keywords: | IFNG IFNG-AS1 Breast cancer long noncoding rnas cells Oncology Surgery |
Divisions: | |
Page Range: | p. 7 |
Journal or Publication Title: | World Journal of Surgical Oncology |
Volume: | 16 |
Identification Number: | 10.1186/s12957-018-1508-1 |
ISSN: | 1477-7819 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3804 |
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