(2019) Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches. Comprehensive Physiology. pp. 75-125. ISSN 2040-4603
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Abstract
Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF. Finally, we discuss cell-based therapies and their possible use to avert the deteriorating nature of HF. (c) 2019 American Physiological Society.
Item Type: | Article |
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Keywords: | mesenchymal stem-cells angiotensin-aldosterone-system mitochondrial permeability transition activated protein-kinase necrosis-factor-alpha matrix-metalloproteinase inhibition helix transcription factor left-ventricular function smooth muscle actin ii type-1 receptor Physiology |
Divisions: | |
Page Range: | pp. 75-125 |
Journal or Publication Title: | Comprehensive Physiology |
Volume: | 9 |
Number: | 1 |
Identification Number: | 10.1002/cphy.c170053 |
ISSN: | 2040-4603 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3766 |
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