(2019) Roles of E6 and E7 Human Papillomavirus Proteins in Molecular Pathogenesis of Cervical Cancer. Current Protein & Peptide Science. pp. 926-934. ISSN 1389-2037
Full text not available from this repository.
Abstract
Human papillomavirus (HPV) cancers are expected to be major global health concerns in the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent expression of oncoprotein which has been poorly taken into account in the cellular communication. Among them, E6/E7 oncoproteins are attractive therapeutic targets as their inhibition rapidly leads to the onset of aging in HPV-positive cancer cells. This cellular response is associated with the regeneration of p53, pRb anti-proliferative proteins as well as the mTOR signaling pathway; hence, the identification of involved and application of E6/E7 inhibitors can lead to new therapeutic strategies. In the present review, we focused on the pathogenicity of E6/E7 Proteins of human papillomavirus and their roles associated with the cervical cancer.
Item Type: | Article |
---|---|
Keywords: | Human papillomavirus cervical cancer E6/E7 proteins oncoprotein cancer cells pathogenicity growth-factor receptor type-16 e6 mediated degradation cell-proliferation life-cycle hpv-16 e6 expression autophagy p53 oncoproteins Biochemistry & Molecular Biology |
Divisions: | |
Page Range: | pp. 926-934 |
Journal or Publication Title: | Current Protein & Peptide Science |
Volume: | 20 |
Number: | 9 |
Identification Number: | 10.2174/1389203720666190618101441 |
ISSN: | 1389-2037 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3745 |
Actions (login required)
View Item |