Abstract

Background and aim: Diabetes is a serious chronic disease that can damage the heart, blood vessels, eyes, kidneys and nerves, leading to death and early disability. Blood glucose control can prevent these complications. Also, a decrease in systolic blood pressure reduces the risk of each complication of diabetes and the risk of death from diabetes. Rhubarb is prescribed in traditional medicine for various patients, including patients with diabetes, high blood lipids and high blood pressure. However, its effect has not been scientifically reported. This study aimed to determine the efficacy of Rhubarb stem extract on hypertension and weight of type II diabetic patients. Methods: In this experimental study, 80 diabetic patients with type 2 diabetes mellitus in the city of Zabol, aged 30-60 years old, fasting blood glucose greater than 140 mg /di and hypertension above 140/90 mmHg, after matching they were randomly divided into two groups of 40 patients treated with Rivas stem capsules and placebo. Patients in both groups were evaluated for blood pressure and weight before and after the study. Results: The mean systolic blood pressure and diastolic blood pressure in the rhubarb group before and after the intervention were 144.87 +/- 8.73 and 95.75 +/- 7.72, respectively, after intervention, to 133.95 +/- 10.98 and 83.73 +/- 25.28 decrease. Paired t-test and Wilcoxon showed a significant decrease in systolic and diastolic blood pressure and diastolic blood pressure with rhubarb intervention (p <0.05), but no significant changes were observed in intervention and weight loss control groups (p <0.05). Conclusion: The use of 400 mg Rhubarb stem capsules three times a day in type 2 diabetic patients can significantly decrease systolic blood pressure and diastolic blood pressure, but there is a significant difference in weight loss between the two groups before and then the intervention did not work.