(2019) Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis. Phytomedicine. pp. 125-136. ISSN 0944-7113
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Abstract
Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.
| Item Type: | Article |
|---|---|
| Keywords: | Bioactive phytochemicals Anticancer phytotherapeutics Chemoprevention Phenylpropanoids Isoprenoids Alkaloids squamous-cell carcinoma e-cadherin expression pancreatic-cancer prostate-cancer signaling pathway down-regulation in-vitro antimicrobial agents cynomorium-coccineum dietary flavonoids Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine |
| Divisions: | |
| Page Range: | pp. 125-136 |
| Journal or Publication Title: | Phytomedicine |
| Volume: | 55 |
| Identification Number: | 10.1016/j.phymed.2018.07.001 |
| ISSN: | 0944-7113 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/3711 |
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