(2019) Protective Effects of Aminoguanidine against Sodium Metavanadate-Induced Spatial Memory Retention Impairment in Morris Water Maze. Pharmaceutical Sciences. pp. 93-99. ISSN 1735-403X
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Abstract
Background: Vanadium is a potential neurotoxic agent widely distributed in the environment. Understanding the neurotoxic mechanisms of vanadium on learning and memory seems necessary. Methods: We investigated the time-dependent (1-week, 2- week and 4-week) effects of sodium metavanadate (SMV) (25 mg/kg/day; pre-training oral administration) and 4-day intraperitoneal injections of aminoguanidine (AG) as a selective inducible nitric oxide synthase inhibitor (10, 50, and 100 mg/kg) on spatial memory retention in Morris water maze. Animals were trained for 4 days and tested 48 h after the last training trial. Results: The data showed that 4-week oral pre-treatment with SMV (25 mg/kg/day) induced spatial memory retention deficits and decreased the time spent in the target quadrant. We found that 4-day administration of different doses of AG during training trials significantly decreased the time and distance of finding the hidden platforms. Additionally, SMV-induced spatial memory retention impairments were prevented in animals received combined SMV (25 mg/kg/day, 4 weeks) and AG (10 mg/kg/day, 4 days). Conclusion: Our findings showed the protective role of AG on SMV-induced spatial memory retention deficits.
Item Type: | Article |
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Keywords: | Sodium metavanadate Inducible Nitric Oxide Synthase Morris water maze Spatial memory nicotine-bucladesine combination nitric-oxide production long-term potentiation intrahippocampal infusion vanadium inhibition hippocampus involvement inhalation expression Pharmacology & Pharmacy |
Divisions: | |
Page Range: | pp. 93-99 |
Journal or Publication Title: | Pharmaceutical Sciences |
Volume: | 25 |
Number: | 2 |
Identification Number: | 10.15171/ps.2019.15 |
ISSN: | 1735-403X |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3666 |
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