(2019) Alleviating Effects of Ursodeoxycholic Acid in Children with Acute Hepatitis A Infection: A Randomized Clinical Trial. Hepatitis Monthly. p. 7. ISSN 1735-143X
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Abstract
Objectives: Ursodeoxycholic acid (UDCA) is a secondary hydrophilic bile acid with alleviating effects on liver enzymes. This study aimed to investigate the effect of UDCA on the improvement of liver enzymes in children with hepatitis A infection. Methods: In this randomized clinical trial, 152 patients were randomly allocated to either intervention (UDCA) or control (no drug) group. Liver enzymes were measured six times within six months post-therapy. Statistical tests were carried out using SPSS 19 software. Results: The mean ALT level reduced from 1296.7 +/- 1236 IU/L to 15.4 +/- 3 IU/L in the UDCA group after six months. ALT also reduced from 1062.3 +/- 959 IU/L to 16.4 +/- 5 IU/L in the control group. The ratio of patients with normal ALT levels was significantly higher in the UDCA group (n = 61, 80.3) than in the control group (n = 51, 68) two months post-therapy (P = 0.06). The mean level of AST reduced from 983.8 +/- 1036 IU/L to 19.4 +/- 5 IU/L in the UDCA group and from 981.8 +/- 1177 IU/L to 22.8 +/- 7 IU/L in the control group. The ratio of patients with normal AST levels was significantly higher in the UDCA group than in the control group one month (n = 34, 44.7 vs. n = 20, 26.7, respectively; P = 0.02), two months (n = 51, 67.1 vs. n = 31, 41.3, respectively; P = 0.001), and three months (n = 66, 86.8 vs. n = 56, 74.7, respectively; P = 0.04) post-therapy. Six months post-therapy, all the patients reached normal AST and ALT levels in both groups. Conclusions: Our results indicated that UDCA accelerated achieving biochemical response in children with acute hepatitis A.
Item Type: | Article |
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Keywords: | UDCA D-Alanine Transaminase Aspartate Aminotransferases Hepatitis A Pediatrics primary biliary-cirrhosis chronic active hepatitis acute viral-hepatitis multicenter interferon mechanisms Gastroenterology & Hepatology |
Divisions: | |
Page Range: | p. 7 |
Journal or Publication Title: | Hepatitis Monthly |
Volume: | 19 |
Number: | 7 |
Identification Number: | 10.5812/hepatmon.86719 |
ISSN: | 1735-143X |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3649 |
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