(2021) Cardioprotective effects of hesperidin on carbon monoxide poisoned in rats. Drug and Chemical Toxicology. pp. 668-673. ISSN 0148-0545
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Abstract
Carbon monoxide (CO) poisoning causes cardiotoxicity and so far, no definite antidote has been proposed to overcome CO-induced adverse outcomes. Hesperidin, a citrus flavonoid, has shown cardio-protective effects in cardiac ischemia/reperfusion models. This study investigated the protective effects of hesperidin against CO-induced cardiac injury. To induce CO poisoning, rats were exposed to CO at 3000 ppm for 60 min. On the exposure day and the four following days, hesperidin (at three different doses of 25, 50, and 100 mg/kg/day) was administered intraperitoneally. A group of animals received normal saline and served as the control group. The electrocardiogram (ECG) was recorded and evaluated with special focus on S-T segment changes (depression or elevation), T-wave alterations, AV block and ventricular and supraventricular arrhythmias. On day 6 (i.e., the day after the last injection day), the animals were sacrificed and the hearts were harvested and evaluated for necrosis using hematoxylin and eosin staining. In addition, Akt protein expression levels and BAX/BCL2 ratio were determined by western blotting. Our results showed that hesperidin decreased cardiac necrosis. In animals treated with hesperidin 100 mg/kg, Akt protein expression was increased, while the BAX/BCL2 ratio was significantly decreased. ECG changes were reversed in all groups 2 h following CO exposure, regardless of hesperidin administration. Overall, hesperidin decreased the deleterious cardiac effects of CO poisoning in rats.
Item Type: | Article |
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Keywords: | Carbon monoxide poisoning Hesperidin Akt protein BAX BCL2 ratio myocardial ischemia/reperfusion injury citrus flavonoids hesperidin colony-stimulating factor 1 protein expression induced cardiotoxicity molecular-mechanisms brain-injury hesperetin bcl-2 resveratrol Chemistry Pharmacology & Pharmacy Toxicology |
Divisions: | |
Page Range: | pp. 668-673 |
Journal or Publication Title: | Drug and Chemical Toxicology |
Volume: | 44 |
Number: | 6 |
Identification Number: | 10.1080/01480545.2019.1650753 |
ISSN: | 0148-0545 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3627 |
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