(2020) Tropisetron attenuates tumor growth and progression in an experimental model of mouse lung cancer. Journal of Cellular Biochemistry. pp. 1610-1622. ISSN 0730-2312
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Abstract
The antineoplastic effects of 5-hydroxytryptamine (5-HT) receptor antagonists have been shown in previous studies. However, the exact underlying mechanisms mediating these antineoplastic effects are unclear. In the present study, we assessed the antineoplastic effects of tropisetron, a 5-HT receptor antagonist, in an experimental model of lung cancer in BALB/c mouse. Lewis lung carcinoma cell line was used to induce lung cancer. Mice were divided into four groups (n = 6) as follows: tumor-bearing mice + tropisetron (5 mg/kg intraperitoneally IP), tumor-bearing mice + tropisetron (10 mg/kg IP), tumor-bearing mice + saline, healthy mice + tropisetron (10 mg/kg). Tumor burden, interferon-gamma (IFN-gamma), interleukin (IL)-4, pathological response, Ki-67, and E-cadherin were assessed using enzyme-linked immunosorbent assay, and real-time polymerase chain reaction. Comet assay was used to assess DNA toxicity. Tropisetrone-treated animals (either 5 or 10 mg/kg) showed significantly lower tumor sizes at the day 24th after tumor induction. Tropisetron received animals also showed significantly higher levels of IFN-gamma, E-cadherin, pathologic response, and necrotic cells compared to the saline-treated counterparts. In addition, the levels of IL-4, and Ki-67 were significantly lower in tropisetrone treated mice in comparison with control. Furthermore, tropisteron coadministration signifcantly reduced H2O2-induced DNA toxicity while treatment with tropisteron alone showed no adverse effect on DNA. Tropisetrone can be used as a potential antineoplastic drug in lung cancer. This agent can promote its antineoplastic effects in part through modulating inflammatory and proliferating markers.
Item Type: | Article |
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Keywords: | lung cancer mice neoplasms tropisetron 5-ht3 receptor antagonist nicotinic acetylcholine-receptor tolfenamic acid induced apoptosis oxidative stress cell-activation chemotherapy involvement inhibition responses Biochemistry & Molecular Biology Cell Biology |
Divisions: | |
Page Range: | pp. 1610-1622 |
Journal or Publication Title: | Journal of Cellular Biochemistry |
Volume: | 121 |
Number: | 2 |
Identification Number: | 10.1002/jcb.29395 |
ISSN: | 0730-2312 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3606 |
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