(2020) Molecular Pathways, Screening and Follow-up of Colorectal Carcinogenesis: An Overview. Current Cancer Therapy Reviews. pp. 88-96. ISSN 1573-3947
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Abstract
Colorectal cancer (CRC) is the development of cancer from the colon or rectum. This kind of cancer presents with a broad spectrum of neoplasms from benign to metastatic forms. The development of the majority of colon cancers appears from adenomatous polyps or adenomas systematically. At least three molecular pathways are involved in CRC pathogenesis including chromosomal instability (CIN), microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Methods such as fecal occult blood tests (FOBTs), colonoscopy, flexible sigmoidoscopy (FOS), computed tomographic colonography (CTC), and fecal DNA are commonly used for CRC screening. The current review discusses the signs and symptoms associated with CRC, molecular pathways related to CRC and some strategies for current screening, diagnosis and treatment.
Item Type: | Article |
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Keywords: | Colorectal cancer (CRC) CIN pathway MSI pathway CIMP pathway diabetes carcinogens island methylator phenotype occult blood-test stool DNA test microsatellite instability colon-cancer serrated pathway colonoscopy diagnosis surveillance mutations Oncology |
Divisions: | |
Page Range: | pp. 88-96 |
Journal or Publication Title: | Current Cancer Therapy Reviews |
Volume: | 16 |
Number: | 2 |
Identification Number: | 10.2174/1573394715666190730111946 |
ISSN: | 1573-3947 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3531 |
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