(2020) A Cross Sectional Survey on Tissue Transglutaminase Auto-Antibodies in Patients with Pulmonary and Extra Pulmonary Tuberculosis. Archives of Clinical Infectious Diseases. p. 5. ISSN 2345-2641
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Abstract
Background: Mycobacterium tuberculosis (TB) is a widespread life-threatening infection worldwide. There is an uncertainty in the association between the emergence of autoimmune antibodies and TB. Objectives: We hereby aimed to screen anti-tissue transglutaminase (anti-tTG) IgA in patients with TB in an Iranian population. Methods: This was a cross sectional study conducted on smear positive TB patients admitted to the Respiratory Diseases Management Center of the city of Zabol, Sistan and Baluchestan Province of Iran during 2017 - 2018. Anti-tTG IgA level was determined using an ELISA kit (Pars Azmoun, Iran). Statistical analyses were performed in SPSS 19 software. Results: Overall, 162 patients were evaluated. Females and males constituted 87 (53.7) and 75 (46.3) of the patients respectively. The mean age was 51.7 +/- 22.3 years (range of 1 - 83). Afghan patients constituted 16 (9.9) and the remaining were Iranians. The therapy course was successfully completed in 78 (48.1) patients, and 67 (41.4) improved following treatments. Overall, 5 patients had active TB with 2 drug-resistant cases. Pulmonary tuberculosis was diagnosed in 127 (78.4) while 35 (21.6) had extra-pulmonary disease. The mean titer of anti-tTG IgA was 22.59 +/- 107.7 (range of 0.8 - 940). Overall, 19 (11.9) of the patients showed elevated levels of the antibody. There was no significant association between anti-tTG IgA titer with neither demographic nor clinical variables. Conclusions: Although anti-tTG IgA antibody test was positive in a relatively high ratio of our patients with TB, the clinical implications of this phenomenon were not significant.
Item Type: | Article |
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Keywords: | Tuberculosis Celiac Disease Tissue Transglutaminase Mycobacterium tuberculosis heat-shock proteins celiac-disease mycobacterial infection children risk Infectious Diseases |
Divisions: | |
Page Range: | p. 5 |
Journal or Publication Title: | Archives of Clinical Infectious Diseases |
Volume: | 15 |
Number: | 2 |
Identification Number: | 10.5812/archcid.86097 |
ISSN: | 2345-2641 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3482 |
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