(2020) Loop-Mediated Isothermal Amplification (LAMP) Assay to Detect Toxoplasmosis in Schizophrenia Patients. Iranian Journal of Parasitology. pp. 299-306. ISSN 1735-7020
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Abstract
Background: Toxoplasma gondii (T. gondit) causes an important parasitic infection known as toxoplasmosis, which is a globally distributed important zoonosis. One of the major serious characteristics of T. gondii is its ability to manipulate the behavior of intermediate hosts. We performed a cross-sectional study to determine toxoplasmosis in schizophrenic patients, as one of the major neuropsychiatric disorders, using loop-mediated isothermal amplification (LAMP) technic by targeting parasite B1 gene. Methods: Blood samples were taken from 118 schizophrenic patients i hospital- in zed tow hospitals including Baharan, Clinic of Psychiatric Ali-ibn-Abi-Talib Hospital (in Zahedan City), and Amir-al Momenin Psychiatric Hospital (in Zabol City), Sistan and Baluchestan Province, southeast Iran in 2016. They were analyzed using LAMP, and compared with the previous data of nested-PCR and serology. Results: Out of the 118 schizophrenic individuals, 56 patients (47.4) were found to be infected with T. gondii. The diagnosis of toxoplasmosis was confirmed in 41 patients (34.7) via the nested-PCR. The seroprevalence of toxoplasmosis in schizophrenic patients was 55.9 (66/118). Conclusion: We found a high efficiency of LAMP method in identifying toxoplasmosis and its high prevalence among schizophrenic patients. Our findings could provide viable offer implications for the prevention of schizophrenia.
Item Type: | Article |
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Keywords: | Loop-mediated isothermal amplification (LAMP) Toxoplasma gondii Toxoplasmosis Schizophrenia gondii infection pcr samples association antibodies disorders risk Parasitology |
Divisions: | |
Page Range: | pp. 299-306 |
Journal or Publication Title: | Iranian Journal of Parasitology |
Volume: | 15 |
Number: | 3 |
ISSN: | 1735-7020 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3462 |
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