(2020) PTEN-induced putative kinase 1 (PINK1) down-regulation in breast cancer samples in association with mitotic rate. Meta Gene. p. 5.
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Abstract
PINK1 codes for a serine/threonine-protein kinase located in the mitochondria. This protein contributes in the pathophysiology of both neurodegenerative diseases and cancer. Its transcription has been shown to be regulated by a natural occurring antisense (AS) RNA named PINK1-AS. We examined expression levels of PINK1 and PINK1-AS in 54 breast cancer specimens versus their nearby non-cancerous tissues. We found significant downregulation of PINK1 in tumoral tissues compared with nearby tissues (P = .003). Yet, expression of PINK1-AS was not remarkably different between tumoral tissues and nearby tissues. Relative expression of PINK1 was associated with mitotic rate (P = .03). We also found trends toward over-expression of PINK1 in younger patient compared with older patients (P = .09) and in grade 2 tumors compared with grade 3 ones (P = .08). The current study delivers further evidences for contribution of PINK1 in the pathophysiology of breast cancer and highlights the context-dependent properties the encoded protein.
Item Type: | Article |
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Keywords: | PINK1 PINK1-AS Breast cancer growth Genetics & Heredity |
Divisions: | |
Page Range: | p. 5 |
Journal or Publication Title: | Meta Gene |
Volume: | 25 |
Identification Number: | 10.1016/j.mgene.2020.100748 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3442 |
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