(2021) Association analysis of HHEX gene variant with type 2 diabetes risk. International Journal of Diabetes in Developing Countries. pp. 43-47. ISSN 0973-3930
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Abstract
Background Type 2 diabetes mellitus (T2DM) is a common, chronic, and complex disorder that is influenced by interactions between genetic and environmental factors. Thehematopoietically expressed homeobox(HHEX) gene, which affects insulin sensitivity and secretion, is a candidate gene for the pathogenesis of T2DM. Objective The purpose of this study was to investigate the effect of theHHEXgenetic variant, rs1111875, on the T2DM risk in a group of Iranian patients for the first time. Methods A total of 108 T2DM patients and 100 normal subjects were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results There was significant difference in genotypes and alleles frequency of rs1111875 between both case and control groups (p < 0.001). The frequency of the G allele was significantly higher in cases (87.5) compared with controls (27) (OR = 18.92, CI = 11.06-32.69,p < 0.001). Conclusion Our findings suggest that the rs1111875 variant of theHHEXgene could be considered a strong risk factor for T2DM development.
Item Type: | Article |
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Keywords: | HHEX rs1111875 T2DM Genetic variant polymorphisms mellitus slc30a8 susceptibility igf2bp2 tcf7l2 cdkal1 Endocrinology & Metabolism |
Divisions: | |
Page Range: | pp. 43-47 |
Journal or Publication Title: | International Journal of Diabetes in Developing Countries |
Volume: | 41 |
Number: | 1 |
Identification Number: | 10.1007/s13410-020-00870-z |
ISSN: | 0973-3930 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3428 |
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