(2021) A review on pain-relieving activity of berberine. Phytotherapy Research. pp. 2846-2853. ISSN 0951-418X
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Abstract
As isoquinoline alkaloid naturally occurs in Coptis and Berberis species, berberine (BER) has shown anti-oxidant, anti-tumour, anti-bacterial and hepatoprotective activities and beneficial effects against digestive, cardiovascular and neurological conditions. Also, BER antiinflammatory, pain-relieving and anti-cholinesterase activities were widely studied. The present overview discusses the analgesic effects of BER. Based on the literature, BER exerted pain-relieving activity against diabetic and chemotherapy-induced neuropathy, and sciatic nerve injury-induced pain via down-regulation of transient receptor potential vanilloid 1, suppression of NF-kappa B and modulation of mu and delta opioid receptors. Besides, BER could repress inflammatory markers tumour necrosis factor-alpha, interleukin-6 and IL-1 beta, as well as prostaglandin E2, inducible nitric oxide synthase and cyclooxygenase-2. The modulatory effects of BER on dopamine and N-methyl d-aspartate systems were also noted. Moreover, BER could induce Nrf2 expression but inhibits p38-MAPK and STAT3 phosphorylation. Noteworthy, anti-cholinesterase activity, which may potentially contribute to BER analgesic properties, warrants particular attention.
Item Type: | Article |
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Keywords: | alkaloids analgesia Berberis vulgaris herbal medicine hyperalgesia natural products nf-kappa-b up-regulation in-vitro morphine inflammation analgesia neurotoxicity metaanalysis resveratrol activation Pharmacology & Pharmacy |
Divisions: | |
Page Range: | pp. 2846-2853 |
Journal or Publication Title: | Phytotherapy Research |
Volume: | 35 |
Number: | 6 |
Identification Number: | 10.1002/ptr.6984 |
ISSN: | 0951-418X |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3396 |
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