(2021) Tadalafil Reversed H-89 - and Scopolamine - Induced Spatial Learning Impairments in Male Rats. Drug Research. pp. 275-283. ISSN 2194-9379
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Abstract
Accumulated evidence shows that the cAMP and cGMP signaling pathway plays an important role in memory function and neuronal plasticity. Phosphodiesterase 5 (PDE5) is a hopeful therapeutic target in AD (Alzheimer disease), and PDE5 inhibition may be a good therapeutic strategy for the treatment of AD. In the present study, the four-day bilateral intra-hippocampal infusion of H-89 as a protein kinase AII inhibitor (10 mu M/side) and intra-peritoneal injections of tadalafil (20mg/kg) and scopolamine (0.5mg/kg) alone and also on combination on spatial learning in Morris water maze (MWM) were investigated. DMSO and saline were used as controls for H-89 and other mentioned drugs, respectively. Rats were trained for 4 days; each day included one block of four trials. Post- training probe trial tests were performed on day 5. Administration of H-89 and scopolamine led to a significant impairment in spatial learning compared to their related controls. But, combination of tadalafil/H-89 or tadalafil/scopolamine reversed H-89 or scopolamine- induced spatial learning deficits in MWM. Taken together, these results showed the probable regulatory effects of cGMP on cholinergic and cAMP/PKA signaling pathways in co-administrations of these mentioned drugs on spatial learning in MWM.
Item Type: | Article |
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Keywords: | cGMP/PKG morris water maze spatial learning PKA II inhibitor scopolamine training intrahippocampal infusion nicotine-bucladesine combination memory retention protein-kinase object recognition oxidative stress nitric-oxide inhibitor celecoxib mouse model deficits Pharmacology & Pharmacy Chemistry |
Divisions: | |
Page Range: | pp. 275-283 |
Journal or Publication Title: | Drug Research |
Volume: | 71 |
Number: | 05 |
Identification Number: | 10.1055/a-1345-7832 |
ISSN: | 2194-9379 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/3377 |
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