Abstract

Using a simple and environmentally friendly method, un-doped and 1 and 5 cadmium doped cerium oxide nanoparticles (Cd doped CeO2 NPs) were prepared through Salvadora persica aqueous extract in the present study. The synthesized nanoparticles were confirmed by Powder X-ray diffraction (PXRD), Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-ray (EDX), Ultraviolet-Visible (UV-Vis), and Raman methods. Due to the results of PXRD, EDX, and UV-Vis, cadmium is well doped in cerium oxide structure. The results of FESEM showed that the synthesized nanoparticles are spherical and have an average size of 10-20 nm. The toxicity effect of synthesized un-doped and Cd doped CeO2 NPs on breast cancer (MCF-7) cell line was investigated using WST-1 test. Compared to doxorubicin as control, the results showed that the un-doped cerium oxide nanoparticles had more cytotoxicity compared with those of the doped nanoparticles and doxorubicin.