(2014) Association of polymorphisms at LDLR locus with coronary artery disease independently from lipid profile. Acta Medica Iranica. pp. 352-359. ISSN 00446025 (ISSN)
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Abstract
Coronary artery disease (CAD) is the leading cause of mortality in many parts of the world. Genome-wide association studies (GWAS) have identified several genetic variants associated with CAD in Low-density lipoprotein receptor (LDLR) locus. This study was evaluated the possible association of genetic markers at LDLR locus with CAD irrespective to lipid profile and as well as the association of these SNPs with severity of CAD in Iranian population. Sequencing of 2 exons in LDLR gene (Exon 2, 12) and part of intron 30 of SMARCA4 gene include rs1122608, was performed in 170 Iranian patients angiographically confirmed CAD and 104 healthy controls by direct sequencing. Sullivan's scoring system was used for determining the severity of CAD in cases. Our results showed that homozygote genotypes of rs1122608 (P<0.0001), rs4300767 (P<0.005) and rs10417578 (p<0.007) SNPs have strong protective effects on the CAD. In addition, we found that rs1122608 (GT or TT) was at higher risk of three vessel involvement compared to single vessels affecting (P=0.01). © 2014 Tehran University of Medical Sciences. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Coronary artery disease LDLR locus Single nucleotide polymorphism SMARCA4 gene BRG1 protein low density lipoprotein receptor DNA LDLR protein, human lipid adult article controlled study disease severity female gene gene frequency gene locus gene sequence genetic association genotype human LDLR gene lipid analysis major clinical study male middle aged scoring system Sullivan's scoring system aged blood genetic polymorphism genetic predisposition genetics polymerase chain reaction Genetic Predisposition to Disease Genome-Wide Association Study Humans Lipids Polymorphism, Genetic Receptors, LDL |
| Divisions: | |
| Page Range: | pp. 352-359 |
| Journal or Publication Title: | Acta Medica Iranica |
| Volume: | 52 |
| Number: | 5 |
| ISSN: | 00446025 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/3257 |
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