(2016) Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy. Nanoscale Research Letters. ISSN 19317573 (ISSN)
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Abstract
Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (GOGA) was characterized using XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy. The release study shows that the release of GA from the designed anticancer nanocomposite (GOGA) occurs in a sustained manner in phosphate-buffered saline (PBS) solution at pH 7.4. In in vitro biological studies, normal fibroblast (3T3) and liver cancer cells (HepG2) were treated with different concentrations of GO, GOGA, and GA for 72 h. The GOGA nanocomposite showed the inhibitory effect to cancer cell growth without affecting normal cell growth. The results of this research are highly encouraging to go further for in vivo studies. © 2016, The Author(s).
| Item Type: | Article |
|---|---|
| Keywords: | Controlled-release Cytotoxicity Drug delivery systems Gallic acid Graphene oxide Cell culture Cell growth Cells Controlled drug delivery Diseases Fourier transform infrared spectroscopy Growth kinetics Nanocomposites Ultraviolet visible spectroscopy Controlled release Drug delivery system Gallic acids Graphene oxides Nano-delivery systems Phosphate buffered saline solutions Technological advancement UV/ Vis spectroscopy Graphene |
| Divisions: | |
| Journal or Publication Title: | Nanoscale Research Letters |
| Volume: | 11 |
| Number: | 1 |
| Identification Number: | 10.1186/s11671-016-1712-2 |
| ISSN: | 19317573 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/3118 |
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