(2017) Evaluation of host–guest system to enhance the tamoxifen efficiency. Artificial Cells, Nanomedicine and Biotechnology. pp. 441-447. ISSN 21691401 (ISSN)
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Abstract
Hydrophobic drugs can absorb as guest molecules inside the cavity of cyclodextrins as host sites. So, forming the drug-cyclodextrin complex can exert a profound effect on the physicochemical and biological properties of the drugs. According to these advantages, in this study, we synthesized the tamoxifen (TMX) loaded cyclodextrin (CD)-conjugated MNPs to evaluate simultaneously the cytotoxicity and sustained release as well as hepatoprotective effect of this nanomedicine. The average size of Fe3O4-DPA-PEG-CD-TMX NPs was approximately 31 nm. By energy-dispersive X-ray spectroscopy (EDS), it was revealed that Fe3O4 constitutes 14.34 of the composition of modified MNPs. In the other words, nearly 85 of Fe3O4-DPA-PEG-CD NPs are made of dopamine (DPA), polyethylene glycol (PEG) and β-cyclodextrin (β-CD). The TMX loaded MNPs (with entrapment efficiency of 33 mg TMX per unit CD (mg) and loading efficiency of 87.5) showed sustained liberation of TMX molecules (with 91 release in 120 h). Cytotoxicity assay and apoptosis assay by TUNEL analysis revealed that the engineered Fe3O4-DPA-PEG-CD-TMX NPs were able to significantly inhibit the MCF-7 breast cancer cells. According to effect of CD on TMX sustained release, it was found that CD can decrease the hepatotoxicity induced by TMX nearly 30. Based upon these findings, we suggest the Fe3O4-DPA-PEG-CD-TMX NPs as an effective multifunctional nanomedicine with simultaneous therapeutic and hepatoprotective effects. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Keywords: | Cyclodextrin drug delivery magnetic nanoparticles tamoxifen Biomaterials Cell death Cyclodextrins Energy dispersive spectroscopy Medical nanotechnology Molecules Nanomagnetics Nanoparticles X ray spectroscopy Biological properties Cyclodextrin complexes Energy dispersive X ray spectroscopy Entrapment efficiency Hepatoprotective effects Magnetic nano-particles MCF-7 breast cancer cells Iron compounds beta cyclodextrin dopamine macrogol magnetic nanoparticle antineoplastic agent beta cyclodextrin derivative drug carrier macrogol derivative magnetite magnetite nanoparticle animal cell apoptosis assay Article cancer inhibition controlled study drug cytotoxicity drug delivery system liver cell liver protection liver toxicity MCF-7 cell line nonhuman particle size rat sustained drug release TUNEL assay animal apoptosis cell survival chemistry cytology dose response drug effects drug formulation drug release female human kinetics physiology primary cell culture procedures transport at the cellular level ultrastructure Animals Antineoplastic Agents beta-Cyclodextrins Biological Transport Dose-Response Relationship, Drug Drug Carriers Drug Compounding Drug Liberation Ferrosoferric Oxide Hepatocytes Humans Magnetite Nanoparticles MCF-7 Cells Polyethylene Glycols Rats |
| Divisions: | |
| Page Range: | pp. 441-447 |
| Journal or Publication Title: | Artificial Cells, Nanomedicine and Biotechnology |
| Volume: | 45 |
| Number: | 3 |
| Identification Number: | 10.3109/21691401.2016.1160916 |
| ISSN: | 21691401 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/3052 |
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