(2013) Targeted delivery of Epirubicin to cancer cells by PEGylated A10 aptamer. Journal of Drug Targeting. pp. 739-44. ISSN 1029-2330 (Electronic) 1026-7158 (Linking)
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Abstract
Clinical administrations of anthracyclines are limited by cardiotoxicity and myelosuppression. Targeted delivery of anticancer agents is especially important in reducing their side effects. In this work, A10 (Apt), an aptamer for prostate-specific membrane anytigen (PSMA), was applied for targeted delivery of Epirubicin (Epi) to LNCaP cells (PSMA(+)). Flow cytometry analysis showed that PEG-Apt-Epi complex was internalized effectively to LNCaP cells (PSMA(+)), but not to PC3 cells (PSMA(-)). This fact was confirmed by less cytotoxicity of PEG-Apt-Epi complex in PC3 cells in comparison with Epi alone. No significant change in viability between Epi- and complex-treated LNCaP cells was observed. In conclusion, PEG-Apt-Epi complex is an efficient and simple system for specific delivery of drug to PSMA-expressing cell lines.
| Item Type: | Article |
|---|---|
| Keywords: | Antigens, Neoplasm/administration & dosage/chemistry Antineoplastic Agents/administration & dosage/chemistry Aptamers, Nucleotide/*administration & dosage/*chemistry Benzeneacetamides/*administration & dosage/*chemistry Cell Line, Tumor Cell Survival/drug effects Drug Delivery Systems/methods Epirubicin/*administration & dosage/*chemistry Humans Male Piperidones/*administration & dosage/*chemistry Polyethylene Glycols/*chemistry Prostatic Neoplasms/drug therapy |
| Divisions: | |
| Page Range: | pp. 739-44 |
| Journal or Publication Title: | Journal of Drug Targeting |
| Volume: | 21 |
| Number: | 8 |
| Identification Number: | 10.3109/1061186X.2013.812095 |
| ISSN: | 1029-2330 (Electronic) 1026-7158 (Linking) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/2964 |
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