(2015) Serologic evaluation of celiac disease in patients with beta thalassemia major and control. Gastroenterology and hepatology from bed to bench. pp. 153-9. ISSN 2008-2258 (Print) 2008-2258 (Linking)
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Abstract
AIM: This study reports evaluated prevalence of CD in patients with Beta-thalassemia major. BACKGROUND: Celiac Disease (CD) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals. PATIENTS AND METHODS: In this case-control study in a period of 3 years, which was performed on 620 children in two groups of Beta-thalassemia major patients (n=200) and control (n=420), serum tissue transglutamianse (tTG) IgA levels were measured. The two groups were compared together in terms of tTG IgA levels, and p<0.05 was considered significant. RESULTS: The means of serum tTG IgA levels in patients with Beta-thalassemia major and control groups were 28.81+/-68.44 and 6.94+/-6.68 U/mL, respectively. There was a significant difference in favor of the case group (p=0.000). Body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001). Belonging to each group will change the probability of having less than 20 in tTG IgA (odds=0.285) and it means that belonging to the control group has a protective role. There is only a significant association in the case of all population (r=0.102, p=0.011). Body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001). CONCLUSION: Probability of CD should be considered since the prevalence of CD is high in patients with and Beta-thalassemia major. Patients with thalassemia major are recommended for screening for CD.
Item Type: | Article |
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Keywords: | Beta-thalassemia major Celiac disease Disease risk Growth disorder Hla |
Divisions: | |
Page Range: | pp. 153-9 |
Journal or Publication Title: | Gastroenterology and hepatology from bed to bench |
Volume: | 8 |
Number: | 2 |
ISSN: | 2008-2258 (Print) 2008-2258 (Linking) |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2927 |
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