(2017) Serum Levels of Tumor Necrosis Factor-alpha and Interleukins in Children with Congenital Heart Disease. The journal of Tehran Heart Center. pp. 15-22. ISSN 1735-5370 (Print) 1735-5370 (Linking)
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Abstract
Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (CHD). We sought to assess the difference in serum cytokines levels between children with and without CHD. Methods: We recruited 60 patients with CHD and 30 healthy children, from 2013 to 2014. Patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine, and chronic inflammatory diseases; fever; infection in the preceding 3 weeks; and malnutrition were excluded. Participants' demographic data were measured, and their cardiac diseases were diagnosed via echocardiography. Serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-18 were measured via ELISA. Results: Mean age of the participants was 4.28 +/- 3.44, 3.12 +/- 3.87, and 3.30 +/- 3.61 years in the cyanotic, acyanotic, and control groups, respectively (p value = 0.414). Mean values of TNF-alpha (p value < 0.001), IL-6 (p value < 0.001), IL-18 (p value = 0.030), right ventricular pressure (p value < 0.001), and pulmonary pressure (p value = 0.015) were higher in the case group, while the BMI was higher in the controls (p value < 0.001). Mean values of TNF-alpha (p value < 0.001), IL-6 (p value < 0.001), and right ventricular pressure (p value < 0.001) were significantly higher in the cyanotic children, whereas the BMI was higher in the controls (p value < 0.001). Levels of TNF-alpha and IL-6 had significant correlations with right ventricular pressure. Conclusion: The present study showed a differed serum cytokines levels between children with and without CHD.
Item Type: | Article |
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Keywords: | Child Heart defects, congenital Interleukins Tumor necrosis factor-alpha |
Divisions: | |
Page Range: | pp. 15-22 |
Journal or Publication Title: | The journal of Tehran Heart Center |
Volume: | 12 |
Number: | 1 |
ISSN: | 1735-5370 (Print) 1735-5370 (Linking) |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2856 |
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