(2008) Chiral Separation of Basic and Zwitterionic Drugs by Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis. Iranian Journal of Pharmaceutical Research. pp. 275-281. ISSN 1735-0328
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Abstract
Due to high resolution power of sulfated cyclodextrins (HS-CDs), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. Experiments were performed on a HP(3D)CE instrument equipped with an on-column diode array UV absorbance detector. Fused silica capillaries with an inner diameter of 50 mu m, an outer diameter of 365 mu m, and a total length of 45.5 cm (8.5 cm to the detector) were used. Capillaries were rinsed with PEO once daily. To reduce analysis time, short-end injection technique was applied. The electrophoretic conditions for the stereoselective analysis of drugs were in the carrier mode with 25 mM sodium phosphate buffer containing 1.25 w/v of each HS-CD at pH 2.5 with an applied voltage of +15 kV. At these conditions, rapid enantioresolution(<= 3.9 min) of all drugs were achieved.
Item Type: | Article |
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Keywords: | chiral capillary electrophoresis highly sulfated cyclodextrins short-end injection basic drugs zwitterionic drugs electromigration techniques pharmaceutical applications zone electrophoresis chromatography enantiomers principles selectors coatings proteins buffers |
Divisions: | |
Page Range: | pp. 275-281 |
Journal or Publication Title: | Iranian Journal of Pharmaceutical Research |
Volume: | 7 |
Number: | 4 |
ISSN: | 1735-0328 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2796 |
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