(2015) Composition, Cytotoxic and Antimicrobial Activities of Satureja intermedia CAMey Essential Oil. International Journal of Molecular Sciences. pp. 17812-17825. ISSN 1422-0067
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Abstract
In this study, the essential oil (EO) constituents from the aerial parts of Satureja intermedia C.A.Mey were detected by GC and GC/MS. The antimicrobial activity of EO on oral pathogens and its cytotoxicity to human cancer cells were determined by the microbroth dilution method and the crystal violet staining method, respectively. Thirty-nine compounds were identified and the main EO constituents were -terpinene (37.1), thymol (30.2), p-cymene (16.2), limonene (3.9), -terpinene (3.3), myrcene (2.5), germacrene B (1.4), elemicine (1.1) and carvacrol (0.5). The S. intermedia EO showed a concentration-dependent decrease in viability of Hep-G2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) human cancer cell lines (p < 0.05). Antimicrobial screening of S. intermedia EO demonstrated slight antibacterial and antifungal activities against Streptococcus mutants, S. salivarius, Enterococcus faecalis, Staphylococcus aureus, Candida albicans and C. glabrata. Further preclinical studies are needed to assess the efficacy and safety of S. intermedia EO as a new promising anticancer agent.
Item Type: | Article |
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Keywords: | gc/ms oral pathogens human cancer cells hepatocellular carcinoma breast adenocarcinoma in-vitro chemical-composition antibacterial activity dental plaque cuneifolia 10 montana l. extracts antifungal iran spicigera |
Divisions: | |
Page Range: | pp. 17812-17825 |
Journal or Publication Title: | International Journal of Molecular Sciences |
Volume: | 16 |
Number: | 8 |
Identification Number: | 10.3390/ijms160817812 |
ISSN: | 1422-0067 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2669 |
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