(2016) Effects of Magnesium Sulfate on the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Mice. Journal of Fundamental and Applied Sciences. pp. 112-123. ISSN 1112-9867
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Abstract
Relapse to opioid, even long time after withdrawal, is one of the most important problems of opiate withdrawal programs. Magnesium has been shown that; inhibit glutamate release and induces N-Methyl-D-aspartate (NMDA) antagonistic effects; moreover, glutamate NMDA antagonists contribute to the reinforcement of morphine. In the current study, the effects of magnesium sulfate on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in an animal model were investigated. The acquisition and extinction and reinstatement phases induced using morphine 40 and 10mg/kg.Magnesium sulfate 300 and 600 mg/kg (not 150mg/kg) reduced morphine dependence. Additionally, tendency of animals to the white compartment of CPP chamber significantly decreased. Magnesium sulfate inhibits morphine tendency and reinstatement probably via NMDA antagonistic effects.
Item Type: | Article |
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Keywords: | magnesium sulfate morphine conditioned place preference controlled-trial acute stroke nmda tolerance reward antinociception potentiation prevents infusion mk-801 |
Divisions: | |
Page Range: | pp. 112-123 |
Journal or Publication Title: | Journal of Fundamental and Applied Sciences |
Volume: | 8 |
Identification Number: | 10.4314/jfas.8vi2s.7 |
ISSN: | 1112-9867 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2644 |
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