(2016) Anticancer Molecular Mechanisms of Resveratrol. Frontiers in Nutrition. ISSN 2296-861X
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Abstract
Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only significantly present in grape products, a huge amount of preclinical studies investigated its anticancer properties in a plethora of cellular and animal models. Molecular mechanisms of resveratrol involved signaling pathways related to extracellular growth factors and receptor tyrosine kinases; formation of multiprotein complexes and cell metabolism; cell proliferation and genome instability; cytoplasmic tyrosine kinase signaling (cytokine, integrin, and developmental pathways); signal transduction by the transforming growth factor-beta super-family; apoptosis and inflammation; and immune surveillance and hormone signaling. Resveratrol also showed a promising role to counteract multidrug resistance: in adjuvant therapy, associated with 5-fluoruracyl and cisplatin, resveratrol had additive and/or synergistic effects increasing the chemosensitization of cancer cells. Resveratrol, by acting on diverse mechanisms simultaneously, has been emphasized as a promising, multi-target, anticancer agent, relevant in both cancer prevention and treatment.
Item Type: | Article |
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Keywords: | stilbenes cancer chemoprevention polyphenols nutritional therapy multi-target agents bioavailability breast-cancer cells to-mesenchymal transition carcinoma a431 cells colon-cancer colorectal-cancer topoisomerase-ii in-vitro signaling pathway induced apoptosis oxidative stress |
Divisions: | |
Journal or Publication Title: | Frontiers in Nutrition |
Volume: | 3 |
Identification Number: | Unsp 8 10.3389/Fnut.2016.00008 |
ISSN: | 2296-861X |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2578 |
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