(2016) Toll-like receptor 2 and type 2 diabetes. Cellular & Molecular Biology Letters. ISSN 1425-8153
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Abstract
Innate immunity plays a crucial role in the pathogenesis of type 2 diabetes and related complications. Since the toll-like receptors (TLRs) are central to innate immunity, it appears that they are important participants in the development and pathogenesis of the disease. Previous investigations demonstrated that TLR2 homodimers and TLR2 heterodimers with TLR1 or TLR6 activate innate immunity upon recognition of damage-associated molecular patterns (DAMPs). Several DAMPs are released during type 2 diabetes, so it may be hypothesized that TLR2 is significantly involved in its progression. Here, we review recent data on the important roles and status of TLR2 in type 2 diabetes and related complications.
Item Type: | Article |
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Keywords: | type 2 diabetes tlr2 complication innate immunity damp pamp myd88 activator protein 1 nf-kb leucine-rich repeats high-fat diet nf-kappa-b chronic periodontitis inflammatory markers interferon-gamma tlr2 expression mellitus interleukin-6 insulin disease |
Divisions: | |
Journal or Publication Title: | Cellular & Molecular Biology Letters |
Volume: | 21 |
Identification Number: | Unsp 2 10.1186/S11658-016-0002-4 |
ISSN: | 1425-8153 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2558 |
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