Abstract

Background: Substance abuse is associated with a wide range of side effects such as hormonal and reproductive disorders. Iranian Crack is a new form of narcotic substance that widely used in Iran during last decade. The aim of this study was determination of the effects of Iranian Crack on serum testosterone and gonadotropin levels in addicted men. Methods: In this case-control study, participants were screened for eligibility, and then, serum levels of testosterone and gonadotropin (LH and FSH) hormones in 54 Iranian Crack addicts men were compared with 45 healthy subjects. Hormone levels in serum were measured by ELISA technique. Results: Results indicated that serum FSH levels in addict men was significantly lower than healthy subjects (p = 0.03). Serum LH and Testosterone levels in case group had not significant difference with control group. Conclusions: According to our results, chronic use of Iranian Crack lead to a reduction in FSH levels, and this reduction may impair the reproductive function in addicted men.