(2017) New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets. Autophagy. pp. 781-819. ISSN 1554-8627
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Abstract
Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still remains a major life-threatening malignancy. CRC etiology entails both genetic and environmental factors. Macroautophagy/autophagy and the unfolded protein response (UPR) are fundamental mechanisms involved in the regulation of cellular responses to environmental and genetic stresses. Both pathways are interconnected and regulate cellular responses to apoptotic stimuli. In this review, we address the epidemiology and risk factors of CRC, including genetic mutations leading to the occurrence of the disease. Next, we discuss mutations of genes related to autophagy and the UPR in CRC. Then, we discuss how autophagy and the UPR are involved in the regulation of CRC and how they associate with obesity and inflammatory responses in CRC. Finally, we provide perspectives for the modulation of autophagy and the UPR as new therapeutic options for CRC treatment.
Item Type: | Article |
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Keywords: | autophagy beclin 1 cancer therapy colorectal cancer er-stress grp78 unfolded protein response endoplasmic-reticulum-stress chaperone-mediated autophagy gene copy number cell lung-cancer stem-like cells group box 1 randomized controlled-trial inflammatory-bowel-disease genome-wide association suppresses tumor-growth |
Divisions: | |
Page Range: | pp. 781-819 |
Journal or Publication Title: | Autophagy |
Volume: | 13 |
Number: | 5 |
Identification Number: | 10.1080/15548627.2017.1290751 |
ISSN: | 1554-8627 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2481 |
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