Abstract

Introduction: According to published statistics by the World Health Organization in 2011, cancer is the second leading cause of death after cardiovascular diseases throughout the world. The American Cancer Society announced in its latest report that out of every eight women, one is diagnosed with breast cancer. The rate of cancer in developed countries is increasing from 1 to 0.2 and in developing countries about 0.5 annually. Methods: In this review article, the databases Medline, Cochrane, Science Direct, and Google Scholar were thoroughly searched to identify the Bone Metastasis of Breast Cancer. In this review, the papers published until early January 2017 that were conducted to study the relationship between the Bone Metastasis of Breast Cancer were selected. Results: Breast cancer cells are different in terms of metastatic ability. Cancer cells separate from the tumor site and reach the secondary tissues. Yet these cells can only be replaced in these tissues if they are grown and proliferated and have the ability to produce new vessels. The metastatic mechanism is complex and its sequence varies according to the target tissue. Discussion and conclusion:. Considering the environmental pollution and various stresses which surround man today, knowing the influence of pathogenic factors detrimental to human health in normal cells and vital molecules is significant which in turn could minimize carcinogenic effects of these agents. There have been plenty of advances in this regard, all of which attempt to prevent the development of cancers and not just to treat the occurred detriment.