Abstract

Introduction: Tuberculosis is the most common cause of death from single-agent infectious diseases in the world, and it is considered to tenth cause of death all over the world; according to estimates, this disease will keep occupying the same position in regard with mortality rate and it might even rise up to the seventh place by 2020. Method: In this review article, the databases Medline, Cochrane, Science Direct, and Google Scholar were thoroughly searched to identify the studies TB diagnostic methods and involved responses. In this review, the papers published until early January 2017 that were conducted to study the TB diagnostic methods and involved responses were selected. In searching for the articles, those English papers were selected that had iTB diagnostic methods and involved responses. Findings: Most common diagnostic methods for tuberculosis include clinical suspicion, response to treatment, chest torsion, direct measles tuberculin test, mycobacterium culture, and Nucleic Acid Amplification methods. The ideal test for active pulmonary tuberculosis should be easy to apply, with highly sensitive and accurate findings; it should be cheap and have the same results under different conditions. Discussion and conclusion: Thus, the presence of complex defense systems in the body is the main cause of resistance against this fatal disease. Medical knowledge can identify the immune response network to this pathogen, which, in turn, helps the development of new-generation vaccines and more effective treatment for fighting as well as possible against this deadly disease.