Abstract

Introduction: Nigella Sativa has a lot of healing properties, such as improving inflammatory, diabetes, cardiovascular, renal and liver diseases. Chemical compounds of back cumin include fixed oils 35-40%, volatile oils -0.05%, proteins 23%, Various amino acids, sugars, mucilages, alkaloids, organic acids, tannins, resins, lipases, phytosterols, vitamins, and various types of minerals; seeds such as timolol thymoquinone and di-thymico-quinone are derived from ferrous oil of Nigella Sativa. Methods: In this review article, the databases Medline, Cochrane, Science Direct, and Google Scholar were thoroughly searched to identify the studies investigating Physiological effects of Nigella Sativa on body. In this review, the papers published until early January 2017 that were conducted to study the Physiological effects of Nigella Sativa on body were selected. In searching for the articles, those English papers were selected that had Physiological effects of Nigella Sativa on body. Results: The results showed that the alcoholic and oil extract of Nigella Sativa on diabetic rats with alloxan glucose decreased the level of serum significantly, compared to untreated groups, after 10 days Discussion and Conclusion: Disturbances in macronutrient metabolism are due to insulin secretion or environmental resistance to insulin in type 2 diabetes, which leads to increased blood glucose, followed by glucose oxidation, non-enzymatic glucose, and the formation of advanced glycation products