(2018) Interactive involvement of hippocampal cAMP/PKA and cyclooxygenase-2 signaling pathways in spatial learning in the Morris water maze. Folia Neuropathologica. pp. 58-66. ISSN 1641-4640
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Abstract
Introduction: Accumulated evidence shows that the cAMP-PKA signaling pathway plays a key role in memory functions. Cyclooxygenase-2, a critical player in neuroinflammation, has been confirmed in the pathogenesis of neurodegenerative diseases. This study is aimed to assess the effect of the interaction of cAMP-PKA and cyclooxygenase pathways on spatial memory acquisition in animal models. Material and methods: In the present study, the effects of the four-day bilateral intra-hippocampal infusions of H-89 as a protein kinase AII inhibitor (10 mu M/side), celecoxib (0.1 M/side) as a selective cyclooxygenase-2 inhibitor, celecoxib/H-89 and bucladesine (10 mu M/side)/celecoxib/H-89 on spatial memory acquisition in the Morris water maze were investigated. Control animals received bilateral intra-hippocampal infusions of dimethyl sulfoxide. Rats were trained for 4 days; each day included one block of four trials. Post-training probe trial tests were performed on day five. Results: A bilateral intra-hippocampal infusion of H-89 and celecoxib led to a significant impairment in spatial learning compared to the controls through a notable decrease in escape latency and traveled distance. But, combination treatment of animals with celecoxib/H-89 and bucladesine/celecoxib/H-89 could considerably reverse celecoxib and H-89-induced spatial memory acquisition impairments in the Morris water maze. Conclusions: These results indicate the probable regulatory effects of cAMP/PKA and cyclooxygenase-2 signaling pathways on spatial memory acquisition in the Morris water maze.
Item Type: | Article |
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Keywords: | cox-2 camp/pka morris water maze spatial memory acquisition hippocampus training intrahippocampal infusion nicotine-bucladesine combination rat cerebral-cortex nf-kappa-b memory retention protein-kinase inhibitor celecoxib glutamate release deficits cox-2 |
Divisions: | |
Page Range: | pp. 58-66 |
Journal or Publication Title: | Folia Neuropathologica |
Volume: | 56 |
Number: | 1 |
Identification Number: | 10.5114/fn.2018.74660 |
ISSN: | 1641-4640 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2266 |
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